Worldwide patterns of human epigenetic variation
نویسندگان
چکیده
منابع مشابه
Worldwide human relationships inferred from genome-wide patterns of variation.
Human genetic diversity is shaped by both demographic and biological factors and has fundamental implications for understanding the genetic basis of diseases. We studied 938 unrelated individuals from 51 populations of the Human Genome Diversity Panel at 650,000 common single-nucleotide polymorphism loci. Individual ancestry and population substructure were detectable with very high resolution....
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The gray wolf (Canis lupus) is a widely distributed top predator and ancestor of the domestic dog. To address questions about wolf relationships to each other and dogs, we assembled and analyzed a data set of 34 canine genomes. The divergence between New and Old World wolves is the earliest branching event and is followed by the divergence of Old World wolves and dogs, confirming that the dog w...
متن کاملSupporting Online Material for Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation
Jun Z. Li, Devin M. Absher, Hua Tang, Audrey M. Southwick, Amanda M. Casto, Sohini Ramachandran, Howard M. Cann, Gregory S. Barsh, Marcus Feldman,* Luigi L. Cavalli-Sforza,* Richard M. Myers* *To whom correspondence should be addressed. E-mail: [email protected] (M.F.); [email protected] (L.L.C.S.); [email protected] (R.M.M.) Published 22 February 2008, Science 319, 1100 (2008)...
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Genome-wide patterns of homozygosity runs and their variation across individuals provide a valuable and often untapped resource for studying human genetic diversity and evolutionary history. Using genotype data at 577,489 autosomal SNPs, we employed a likelihood-based approach to identify runs of homozygosity (ROH) in 1,839 individuals representing 64 worldwide populations, classifying them by ...
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Genome-wide patterns of variation across individuals provide a powerful source of data for uncovering the history of migration, range expansion, and adaptation of the human species. However, high-resolution surveys of variation in genotype, haplotype and copy number have generally focused on a small number of population groups. Here we report the analysis of high-quality genotypes at 525,910 si...
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ژورنال
عنوان ژورنال: Nature Ecology & Evolution
سال: 2017
ISSN: 2397-334X
DOI: 10.1038/s41559-017-0299-z